HiPerGator-RV (ResVault) is a secure computing environment (encrypted enclave) where scientists and collaborators can conduct research on restricted and confidential data. HiPrGator-RV (ResVault) is designed to run virtual machines that are secure and pre-approved with the capacity for large-scale data storage and computation. ResVault VMs act as workstations with remote access. The environment is compliant with NIST 800-151 rev2 to handle Controlled Unclassified Information (CUI) as required, for example, by with the regulations for Export Administration Regulations (EAR) Controlled and International Traffic in Arms Regulations (ITAR) data, Health Insurance Portability and Accountability Act (HIPAA) law on protection of ePHI (electronic protected health information) as well as the Family Educational Rights and Privacy Act (FERPA) on protection of student information.